A Single Protein Targeted as a Potential Root Cause of Multiple Childhood-Onset Psychiatric Disorders

A new discovery recently published in The FASEB Journal links the malformation of a single protein, called “SRGAP3”, to problems in brain functioning that cause symptoms akin to some mental health disorders seen in children. This finding offers a new target for the development of treatments that aim to reverse the biological cause, rather than treat the symptoms.

This study used mice with an inactivated SRGAP3 protein. These mice showed clear changes in brain anatomy, resulting in altered behavior that showed similarities to human neurological and psychiatric diseases. If SRGAP3 abnormalities are apparent in multiple brain disorders, it could be a possibly link between them.

The development of brain disorders such as schizophrenia, mental retardation and autism is quite devastating in children and young adults. Finding a commonality between these disorders will aid in discovering potentially powerful treatments in preventing or reversing onset of these disorders.

 

Link: http://www.sciencedaily.com/releases/2012/10/121031132752.htm:

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Child Protection

It was late at night, and you were just about to go to bed when you heard a scream. It came from downstairs. In fact, you were almost certain that it came from that 10-year-old who lived downstairs with her mother. You looked at the clock and it was 1am; it wasn’t a time when a 10-year-old should still be awake.

But again, you might be wrong. After all, it was late and you were sleep deprived. You got into bed and turned off the light, when you heard another scream, along with an angry voice. You couldn’t make out what exactly they were saying, but it sounded like a heated argument. What should you do?

You turned up the light and grabbed your phone. Should you call the police? Should you wake your friend up in the middle of the night and get a second opinion? As you sat there, struggling, it quieted down. Maybe it was nothing. Maybe the child just had too much candy earlier and refused to go to bed. That child was definitely a screamer. You remembered hearing her scream in the afternoon when she was playing outside.

Now it was all quiet, and you put down the phone. It was no big deal, you thought to yourself, people tend to get over-anxious in the middle of the night. But then, it came again. It was the loudest scream ever, and you could have sworn you heard someone hit something.

Okay, this was enough. You took out your phone and were about to dial. But again, you hesitated. Why wasn’t anyone else doing anything? Were you the only one who heard this? Why didn’t their neighbors call? At the same time, you remembered watching it on TV, where child services workers would come unannounced and grab babies, taking them away from the mother. If you had caused that mother to lose her daughter, you definitely wouldn’t be able to sleep with that.

As much as I hope none of us would ever have to face this kind of situation, chances are that some of us will, and some of us have. While there might be a dozen reasons why you wouldn’t want to report (such as the bystander effect), there is one sufficient reason why you would – because the law says so. Under Child, Family and Community Service Act, Chapter 46, anyone with reason to suspect child abuse has the legal obligation to report to the authorities.

Of course, it might also be nice to know that child services don’t just come and snatch babies like what’s shown on Hollywood. Although in extreme cases, children might have to be taken away from the parents for their own safety, in most cases, they try to use counseling and support to keep the family together. They know, for example, that depression is sometimes the cause of domestic violence, so they might try to provide treatment for the parents’ depression, in the hope that it will diminish future child abuse.

Child abuse and neglect is associated with a huge variety of mental illnesses, such as depression, anxiety, and personality disorders. Not to mention that abused children are likely to grow into abusive parents themselves, too. Next time when you encounter a situation like this and have to report someone, try to do it with pride – at least you have enough courage and knowledge to do it. Any by doing it, you might have just saved someone’s life.

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New study shows that too much exercise can negatively impact our mental health

 

A new study out of Columbia University showed that while those who exercise 2.5-7.5 hours per week have better mental health than average, any more than that tends to result in the reverse.

Researchers found that “about 65 percent of those with poorer mental health exercised more than four hours per week, compared to 55 percent of adults in better mental health.”

Moreover, they were surprised to discover that when 7.5 hours of exercise were exceeded each week, symptoms of depression and anxiety rose significantly.

With Bulima impacting up to 19% of females on university campuses and body dysmorphia in males on the rise, its important to keep those societal expectations about how our bodies should look, in-check.

As students our expectations of ourselves and from others are high. Be cautious to not take on too much all at once, we are only human after-all. If you feel like yourself or anyone you know is suffering mentally because of exercise or weight-loss issues please check out the Counselling, Health and Wellness page page to expose some myths as well as get some resources. Or drop into to the wonderful people in Counselling Services to get some one-on-one or group support with image problems or for anything else that  is bugging you.

And don’t let this odd, ominous cloud that’s looming over campus get you down MHAC! We just got to keep on keepin’ on.

Jess

 

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Volunteer opportunity: Research study

Share your views on help seeking and campus support services: Contribute to innovative research from the University of Alberta

Featurng guest writer, Erica Lauridsen, PhD Candidate, University of Alberta

Are you a full-time student studying at the University of British Columbia?

Are you interested in participating in a research study about help seeking & campus support services?

We are looking to conduct 1:1 interviews to determine what prevents students from seeking help on campus and how support services can be modified to better meet the needs of students.

Interviews will be 1-2 hours in length. The interviews will be confidential and can be completed on campus, over the phone, or via Skype.

For more information or if you are interested in participating, please contact Erica Lauridsen at lauridse@ualberta.ca or 780.850.0561.

This study has been approved by the University of Alberta REB 1 and the University of British Columbian BREB.


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The New Criteria for Diagnosing Hypersexual Disorder

The idea of out-of-control sexual behavior as a mental health disorder has oftentimes been dismissed due to lack of scientific evidence. In fact, sexual addiction is frequently regarded as comical and presented in such a way in movies and TV shows. However, a UCLA-led team of experts has developed a proposed set of criteria to define “hypersexual disorder” as a mental health condition, and has via testing shown that the criteria are reliable and valid in allowing for the diagnosis of sex addiction.

The results of their study will affect whether hypersexual disorder will be included in the upcoming revised fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5).

The criteria establish that a number of symptoms must be present for diagnosis, including a recurring pattern of sexual fantasies, urges and behaviors which last six months or longer, and are not induced by other factors such as substance abuse, medical conditions or manic episodes associated with bipolar disorder. As well, individuals must show a relationship between heightened sexual activity and depression or stress. As well, individuals must be unsuccessful in their tries to limit detrimental sexual activities.

Testing involved recruitment of 207 patients, all of whom were seeking help for out-of-control sexual behavior, substance-abuse disorder or other psychiatric conditions, such as depression or anxiety. The proposed criteria for hypersexual disorder accurately classified 88 percent of the patients as having the disorder. As well, it was able to discriminate those who did not meet the criteria for hypersexual disorder 93 percent of the time.

This study has shed light on the oftentimes debilitating condition of hypersexual disorder, which can make living a healthy life very difficult, potentially destroying relationships and putting the individual at risk for health concerns, such as sexually transmitted diseases. A proper early diagnosis of the disorder, if included in the DSM-5 can help the individual with recovery and re-gaining of a stable life.

 

Link: http://www.sciencedaily.com/releases/2012/10/121019102802.htm

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